Revised response criteria for polycythemia vera and essential thrombocythemia: an ELN and IWG-MRT consensus project
نویسندگان
چکیده
منابع مشابه
Response criteria for essential thrombocythemia and polycythemia vera: result of a European LeukemiaNet consensus conference.
European experts were convened to develop a definition of response to treatment in polycythemia vera (PV) and essential thrombocythemia (ET). Clinicohematologic (CH), molecular, and histologic response categories were selected. In ET, CH complete response (CR) was: platelet count less than or equal to 400 x 10(9)/L, no disease-related symptoms, normal spleen size, and white blood cell count les...
متن کاملManagement of polycythemia vera and essential thrombocythemia.
The optimal management of patients with polycythemia vera (PV) and essential thrombocythemia (ET) continues to be controversial. Both diseases present diagnostic challenges and there is a paucity of data from randomized clinical trials to guide therapeutic decisions. However, the past two years have seen major advances in our understanding of these myeloproliferative disorders (MPD). First, the...
متن کاملComments on ELN Recommendations to Diagnosis, Prognosis and Treatment of Polycythemia Vera and Essential Thrombocythemia
Introduction The new genetic and clinical notions on classic myeloproliferative neoplasms (MPN) polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF) have modified our criteria for diagnosis, prognosis and therapy but it is as still unclear whether these concepts can be translated into changes of the management of individual patient with MPN. For this reason, an...
متن کاملPlatelet activation and inhibition in polycythemia vera and essential thrombocythemia.
Persistently enhanced platelet activation has been characterized in polycythemia vera (PV) and essential thrombocythemia (ET) and shown to contribute to a higher risk of both arterial and venous thrombotic complications. The incidence of major bleeding complications is also somewhat higher in PV and ET than in the general population. Although its efficacy and safety was assessed in just 1 relat...
متن کاملThe 2008 WHO diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis.
Several international working groups cooperated to propose new diagnostic guidelines for polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) to the steering committee of the World Health Organization. Because JAK2 mutation status presents a decisive diagnostic test in PV, this feature was introduced as a major criterion. Minor criteria, such as characteristic...
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ژورنال
عنوان ژورنال: Blood
سال: 2013
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2013-01-478891